Abstract
A Ohsaki, N Venturelli, TM Buccigrosso. J Exp Med. 2018;215(1):91–113 To investigate whether maternal allergen sensitization affects offspring susceptibility to food allergy and the mechanism of this induction of tolerance. This was a murine study. Nonatopic breastfeeding human mothers who had no personal or family history of atopic diseases and who had no other chronic diseases or mastitis during the preceding 4 weeks were also recruited. The investigators conducted a series of experiments to study the importance of maternal sensitization, regulatory T cells (Tregs), and immunoglobulin–allergen immune complexes (Ig-ICs) in breast milk on the development of allergy in the offspring. Female mice were epicutaneously sensitized with egg white protein ovalbumin followed by epicutaneous sensitization and oral challenge of their offspring with ovalbumin. Tregs were identified by their known surface markers (cluster of differentiation 4 and forkhead box p3) and were measured in the mesenteric lymph nodes (MLNs) of offspring of ovalbumin-sensitized or naive …
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