Abstract
Objective:Positive family history is associated with increased type 2 diabetes (T2D) risk, and reflects both genetic and environmental risks. Several studies have suggested an excess maternal transmission of T2D, although the underlying mechanism is unknown. We aimed to examine the association between maternal diabetes and cardiometabolic risk in the offspring.Methods:Parental history of diabetes and clinical data including anthropometric traits, fasting plasma glucose and insulin (FPG, FPI), blood pressure and lipid profile were collected from 2581 unrelated Chinese offspring (2026 adolescents from a population-based school survey and 555 adults from a community-based health screening programme). A subset of subjects (n=834) underwent oral glucose tolerance test to measure the glucose and insulin concentrations at 0, 15, 30, 60 and 120 min for evaluation of the areas under the curve (AUC) of glucose and insulin at 0–120 min, homoeostasis model assessment of insulin resistance (HOMA-IR) and bell-cell function, insulinogenic index, insulin sensitivity index (ISI) and oral disposition index (DI).Results:A positive parental history of diabetes was associated with increased risk of obesity (odd ratios (OR) (95% confidence interval (CI))=1.48 (1.10–2.00)), central obesity (OR (95% CI)=1.67 (1.21–2.32)), higher FPI, HOMA-IR, 2-h insulin, AUC of glucose at 0–120 min, triglycerides, reduced ISI and DI. Compared with individuals without parental diabetes, offspring with diabetic mother had significantly increased risk of obesity (OR (95% CI)=1.59 (1.07–2.35)), central obesity (OR (95% CI)=1.88 (1.23–2.88)), higher glucose levels and BP, were more insulin resistant but also had impaired first-phase insulin response and worse lipid profile. However, paternal history of diabetes had no effect on any of the studied traits, except higher body mass index, waist circumference in females and FPG.Conclusions:Our findings suggested that maternal history of diabetes conferred increased risk of cardiometabolic abnormalities, and was associated with both insulin resistance and impaired first-phase insulin secretion. Further investigation into the mechanism of transgenerational diabetes is warranted.
Highlights
With the adoption of a modern lifestyle and the lack of physical activity, there has been a twofold increase in the prevalence of type 2 diabetes (T2D) in China during the last two decades.[1]
We aimed to examine the associations of cardiometabolic risk factors with (1) PH of diabetes; (2) paternal history of diabetes; (3) maternal history of diabetes; and (4) biparental history of diabetes in two independent cohorts of Chinese adolescents and adults
We have found evidence for familial clustering of diabetes and maternal influence on increasing total cholesterol level in Chinese patients with T2D.6
Summary
With the adoption of a modern lifestyle and the lack of physical activity, there has been a twofold increase in the prevalence of type 2 diabetes (T2D) in China during the last two decades.[1]. Our previous study observed a higher frequency of diabetes in mother than in father among T2D patients.[6] women with gestational diabetes have been more frequently reported to have a diabetic mother than a diabetic father.[12] Animal models demonstrated the effect of maternal diabetes on impaired glucose tolerance in their offspring.[13] Some[6,8,14,15,16,17,18,19,20,21,22,23,24,25,26,27] but not all[5,7,28,29,30] studies reported that offspring with maternal history of diabetes are more likely to develop diabetes and cardiometabolic disorders such as obesity, impaired glucose tolerance, insulin resistance, hyperinsulinaemia and dyslipidaemia compared with those with paternal history of diabetes. We estimate the odd ratios (ORs) (95% confidence intervals (CIs)) for obesity and central obesity by comparing subjects with PH of diabetes to those without PH of diabetes
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