Maternal Genitourinary Infection Appears to Synergistically Increase the Risk of Epilepsy in Children of Women with Epilepsy

Abstract

Background: Evidence indicates that maternal genitourinary infection during pregnancy is associated with increased risk of epilepsy in children and that children of women with epilepsy are substantially more likely to have epilepsy themselves. Research is lacking on whether maternal genitourinary infection has a different effect on children of women with epilepsy compared to children of women without epilepsy. Methods: We conducted a retrospective cohort study using Medicaid data for 127,540 pregnancies, from 1996 to 2002, and children’s data through 2008. Maternal epilepsy, genitourinary infections, and child epilepsy were identified. Epilepsy was diagnosed in 1.7% of the children in the cohort. Results: There was a statistically significant interaction between maternal genitourinary infection and maternal epilepsy. Maternal genitourinary infection was strongly associated with increased risk of epilepsy in children of women with epilepsy (hazard ratio = 3.74, 95% CI = 1.67–8.40). Infection was more weakly associated with increased risk of epilepsy in children of women without epilepsy (hazard ratio = 1.23, 95% CI = 1.12–1.34). Conclusions: There is a significant association between genitourinary infection and childhood epilepsy, and the impact appears to be greater in children of women with epilepsy. This finding has implications for prenatal care of women with epilepsy as well as for research on antenatal risk factors for child epilepsy.