Abstract
Maternal gatekeepers: How maternal antibody Fc characteristics influence passive transfer and infant protection.
Highlights
OPEN ACCESSCitation: Langel SN, Otero CE, Martinez DR, Permar SR (2020) Maternal gatekeepers: How maternal antibody Fc characteristics influence passive transfer and infant protection
Maternal antibodies (MatAbs) can interfere with the neonatal immune response, after vaccination [6]. This Pearl explores the role of monomeric immunoglobulin G (IgG), the only antibody isotype to cross the placenta, and polymeric IgA, the major antibody species in breast milk, and their Fc domain characteristics on passive transfer to and functional activity in the newborn
Kim and colleagues demonstrated that B-cell responses to a live attenuated measles vaccine were inhibited by passively transferred measles-specific IgG antibodies in a FcγRIIB-dependent manner, suggesting that IgG Fc region characteristics contribute to suppression of the immune response [41]
Summary
Maternal antibodies (MatAbs) passively transferred across the placenta and into breast milk are critical for protection against infectious disease and immune development during the first year of life [1]. Maternal dimeric immunoglobulin A (dIgA) antibodies transfer into breast milk by binding to the polymeric immunoglobulin receptor (pIgR) on MG epithelial cells through the antibody joining chain (J-chain) [4] and provide immune protection in the gut while shaping microbiota colonization [4,5].
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