Abstract
Maternal exposure to air pollution during pregnancy is associated with adverse outcomes in the offspring, but limited studies focused on the impacts of gaseous air pollution on newborn congenital hypothyroidism (CH). Therefore, a national data-based analysis was conducted to explore the association between maternal exposure to gaseous air pollution and the incidence of CH in China. Annual average exposure levels of SO2, NO2, CO, and O3 from January 1, 2014, to December 30, 2014, were acquired from the Chinese Air Quality Online Monitoring and Analysis Platform. The annual incidence of newborn CH from October 1, 2014, to September 30, 2015, was collected from the Chinese Maternal and Child Health Surveillance Network. Temperature and toxic metal in wastewater in 2014 were also collected as covariates. Maternal exposure to O3 and NO2 in 1 μg/m3 level increment was positively associated with newborn CH, with an OR of 1.055 (95% CI 1.011, 1.102) and 1.097 (95% CI 1.019, 1.182) after adjusting for covariates completely. Compared with the lowest level of O3, maternal exposure to the 4th quartile of O3 was positively associated with newborn CH (OR 1.393, 95% CI 1.081, 1.794) after adjusting for covariates completely. And the 3rd and 4th quartiles of NO2 were associated positively with CH (OR 1.576, 95% CI 1.025, 2.424, and OR 1.553, 95% CI 0.999, 2.414, respectively) compared with the lowest level of NO2. By fitting the ROC curve, 93.688 μg/m3 in O3 might be used as cutoff to predict the incidence of newborn CH in China.
Highlights
Atmospheric pollution has become a global environmental burden and caused widespread public concern (Gao et al 2016)
low birth weight (LBW), preterm birth (PTB), and gestational diabetes mellitus (GDM) were confirmed to be associated with maternal exposure to air pollution, which may affect the occurrence of newborn congenital hypothyroidism (CH) indirectly (David et al 2018)
Data from 30 provinces in China were applied to the analysis, including the incidence of newborn CH from October 1, 2014, to September 30, 2015, gaseous air pollutants (SO2, NO2, carbon monoxide (CO), and O3) in 2014, toxic metal in wastewater and temperature in 2014 (January 1, 2014, to December 30, 2014)
Summary
Atmospheric pollution has become a global environmental burden and caused widespread public concern (Gao et al 2016). Pregnancy is critical for the whole life process; multiple factors including maternal exposure to air pollution during pregnancy could cause adverse outcomes in pregnant women and infants. Researches on air pollution during pregnancy were mainly focused on maternal complications, fetal development, and congenital malformation; limited studies paid attention to metabolic diseases such as newborn congenital hypothyroidism (CH) (Li et al 2019). LBW, PTB, and GDM were confirmed to be associated with maternal exposure to air pollution, which may affect the occurrence of newborn CH indirectly (David et al 2018). It is necessary to explore the influential association between maternal exposure to air pollution and the occurrence of newborn CH. We are going to explore the associations between maternal exposure to gaseous air pollutants and the newborn incidence of CH. We hope to calculate the cutoff value of air pollutants, and it may be helpful to set an interim goal in air pollution control, and to reduce the incidence of newborn CH in China
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
