Abstract
Maternal exposure to fine particulate matter during pregnancy induces progressive senescence of hematopoietic stem cells under preferential impairment of the bone marrow microenvironment and aids development of myeloproliferative disease
Highlights
To the Editor: During the last few decades, industrial development and expansion have led to significantly increased levels of fine particulate matter (PM) in the air, including particles with aerodynamic diameters smaller than 2.5 μm [1]
Little is known about the mechanisms underlying the effects of PM2.5 on stem progenitor cells, hematopoietic stem progenitor cells (HSPCs)
We developed an atmospheric simulation chamber (ASC) (Supplementary Fig. 1a), and demonstrated that maternal exposure to PM2.5 (2 h on five consecutive days, ~50 μg/m3 PM2.5 mass concentration, Supplementary Tables 1 and 2, Supplementary Fig. 1b, c) during pregnancy can affect the lungs of the fetus
Summary
To the Editor: During the last few decades, industrial development and expansion have led to significantly increased levels of fine particulate matter (PM) in the air, including particles with aerodynamic diameters smaller than 2.5 μm (referred to as PM2.5) [1]. There is growing evidence regarding the detrimental risks to the embryo and offspring that have been maternally exposed to PM2.5 during pregnancy [4,5,6], little is known about the effects of maternal PM2.5 exposure to stem cells, which begin to emerge, activate, and mature during embryo development.
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