Abstract
Maternal lipid profiles during pregnancy are associated with risk for preterm birth. This study investigates the association between maternal dyslipidemia and subsequent preterm birth among pregnant women in the state of California. Births were identified from California birth certificate and hospital discharge records from 2007–2012 (N = 2,865,987). Preterm birth was defined as <37 weeks completed gestation and dyslipidemia was defined by diagnostic codes. Subtypes of preterm birth were classified as preterm premature rupture of membranes (PPROM), spontaneous labor, and medically indicated, according to birth certificate data and diagnostic codes. The association between dyslipidemia and preterm birth was tested with logistic regression. Models were adjusted for maternal age at delivery, race/ethnicity, hypertension, pre-pregnancy body mass index, insurance type, and education. Maternal dyslipidemia was significantly associated with increased odds of preterm birth (adjusted OR: 1.49, 95%CI: 1.39, 1.59). This finding was consistent across all subtypes of preterm birth, including PPROM (adjusted OR: 1.54, 95%CI: 1.34, 1.76), spontaneous (adjusted OR: 1.51, 95%CI: 1.39, 1.65), and medically indicated (adjusted OR: 1.454, 95%CI: 1.282, 1.649). This study suggests that maternal dyslipidemia is associated with increased risk for all types of preterm birth.
Highlights
Preterm birth is defined as delivery prior to 37 weeks of completed gestation
The present study investigates the association between a clinical diagnosis of maternal dyslipidemia and subsequent preterm birth among pregnant women in the state of California
The group of women who had dyslipidemia included more Black women, were less likely to have a normal body mass index (BMI), were more likely to have hypertension, were less likely to be on Medi-Cal insurance, were more likely to have completed more than 12 years of education, and were slightly older than the group of women without dyslipidemia
Summary
Preterm birth is defined as delivery prior to 37 weeks of completed gestation. The World Health Organization estimates that preterm birth affects 11% of pregnancies worldwide, representing nearly 15 million births in 2010 [1]. Despite decades of research into the causes of preterm birth, the biological causes of preterm birth remain largely unknown [2].
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