Abstract
Umbilical cord blood (UcB) is a rich source of stem cells which are used in the treatment of approximately different 80 disease units. Stem cells are stored in both state and private banks and it is crucial that optimal conditions for obtaining UCB are developed to ensure the highest viability of the preserved stem cells. The aim of the paper is to determine the correlation between the length of pregnancy, the number of deliveries, the newborn’s birth weight, and selected properties of UCB stem cells. The study covers 50 pregnant females in whom either spontaneous labor or elective caesarean section were performed. UCB was collected immediately upon birth and the samples were analyzed in a Polish stem cell bank in Warsaw. The authors found that as the length of the pregnancy increases, so does the concentration of nucleated cells in UCB. However, tested parameters of UCB were not related to the number of deliveries or newborn’s birth weight.
Highlights
For many years the umbilical cord blood (UCB) has been widely used as an alternative source of stem cells for transplantation purposes due to its large number of multipotent stem cells and their immunological incompetence, virological purity, accessibility, and ease of collection
The first UCB bank was established by Rubinstein in 1992 in New York [1]
In 1996 it was proven that the number of stem cells present in a single unit of frozen UBC is enough to recreate the bone marrow of three recipient and that UCB transplantation is associated with a lower risk of graft rejection [3]
Summary
For many years the umbilical cord blood (UCB) has been widely used as an alternative source of stem cells for transplantation purposes due to its large number of multipotent stem cells and their immunological incompetence, virological purity, accessibility, and ease of collection. In 1996 it was proven that the number of stem cells present in a single unit of frozen UBC is enough to recreate the bone marrow of three recipient (a child) and that UCB transplantation is associated with a lower risk of graft rejection [3]. These events led to the creation of consecutive UCB banks and various programs of financing them from public funds. As a result it became critical to establish standards and protocols for collecting, processing, and storing umbilical cord blood
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