Abstract
To study the maternal and neonatal outcomes of pregnancy complicated with Systemic Lupus Erythematosus (SLE). Clinical data of 84 pregnant women complicated with SLE were collected. All patients were divided into the different groups based on the pregestational status of SLE, SLE status during pregnancy and the type of medicine administration respectively. The incidence rates of pregnancy loss and preterm labor in the pregestational and gestational stable SLE groups were significantly lower and the incidence rate of full-term labor was considerably higher than those in the active SLE groups. In the pregestational stable SLE group, the incidence of PIH was significantly lower than that in the active SLE group. The incidence of PIH and FGR in the gestational active SLE group was dramatically higher than that in the gestational stable SLE group. Among 84 women, 56 (66.7%) received cesarean section, 18 (21.4%) vaginal delivery and 10 (11.9%) labor induction. The status of SLE is intimately correlated with maternal and neonatal outcomes. PIH is a major complication of active SLE and associated with adverse pregnancy outcomes. SLE can cause congenital fetal injury, especially congenital heart block.
Highlights
Systemic lupus erythematosus (SLE) is an autoimmune disease
The initial onset of SLE was observed in 6 women (7.1%) during pregnancy, in 32 (38.1%) during the 1st pregnancy, in 29 (34.5%) during the 2nd pregnancy, in 23 (27.4%) during the 3rd pregnancy, SLE complicated with APS in 6 (7.1%), LN in 7 (8.3%) and thrombocytopenia in 8 patients, accounting for 9.5%
SLE pregnant women have a high risk of adverse pregnancy outcomes and SLE recurrence
Summary
Systemic lupus erythematosus (SLE) is an autoimmune disease. In this disease, the body’s immune system mistakenly attacks healthy tissue. More and more efforts have been attached to the understanding, diagnosis and treatment of pregnancy complicated with SLE. The relationship between pregnancy and SLE remains elusive and complicated (Stojan & Baer, 2012). Previous studies have demonstrated that SLE pregnant woman can obtain relatively favorable pregnancy outcomes (Carmona et al, 1999), whereas other scholars have found that the incidence of adverse pregnancy outcomes in SLE pregnant women is higher compared with that in healthy counterparts (Chen et al, 2015; Ku et al, 2016). SLE pregnant women have a higher risk of pregnancy-induced hypertension syndrome (PIH), fetal growth restriction (FGR), fetal distress, pregnancy loss, preterm labor and other adverse pregnancy outcomes compared with those of healthy counterparts
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