Maternal and Neonatal Outcomes in Multiple Gestations With Elevated Antenatal Edinburgh Depression Scale (EDS) [6R

Abstract

INTRODUCTION: The purpose of this study was to determine the association of elevated antenatal Edinburgh Depression Scale (EDS) and maternal and neonatal outcomes in multiple gestations, in particular the rate of preterm delivery. METHODS: This is a retrospective study examining multiple gestations delivering at UC San Diego between 2010-2014. Patients were included if they completed an antepartum EDS. An EDS score of >10 was considered positive. The primary outcome was rate of preterm delivery (GA at delivery of < 37 weeks). Other maternal and neonatal outcomes of interest included history of preterm delivery, birth weight percentage and discordance, Apgar score, and maternal weight gain. Data was analyzed using SPPS v.23. RESULTS: 102 women with multiple gestations completed an antepartum EDS. 22.5% (23/102) had a positive EDS score and 77.5% (79/102) had a negative score. Preterm delivery rate in the entire cohort was 61.8% (N=63). Women with an elevated EDS score had a trend toward higher preterm delivery rate (73.9%, N=17) compared to women with lower EDS scores (58.2%, N=46), p-value=0.23. A higher proportion of neonates born to mothers with elevated EDS had an Apgar score less than 7 at 5 minutes (27.3% vs 12.1%, p-value=0.1) although this was not statistically significant. No differences were noted in maternal weight gain or birth weight discordance. CONCLUSION: There is a trend toward an increased rate of preterm delivery and lower Apgar score in multiple gestations with a positive antepartum maternal EDS score. Further studies are needed to assess if treating these high-risk patients reduces their rate of preterm delivery.