Abstract
In late December 2019, the COVID-19 pandemic caused a great threat to people’s lives worldwide. As a special category of the population, pregnant women are vulnerable during emergencies. This study was designed to explore whether or not the COVID-19 pandemic has influenced maternal and infant outcomes. We collected maternal characteristics, laboratory results, condition in the third trimester, maternal outcome, fetal or neonatal outcomes, and characteristics of amniotic fluid, umbilical cord and placenta from pregnant women and fetals or newborns in the first affiliated hospital of Jinan university from 24 January to 31 March 2020 (peak period), chose the same types of data at the hospital during the same period in 2019 and 1 January—23 January 2020 (prior to the outbreak of COVID-19 in 2020) as a control. Our study focused on uncomplicated singleton pregnancies among women not infected by COVID-19. The results demonstrated that there was not an increase in adverse outcomes of pregnant women and newborns during the COVID-19 pandemic; This might be associated with the updated design of major epidemic prevention and control systems in Guangzhou, and the extension of pregnant women’s rest time during the third trimester of pregnancy. Nevertheless, the survey showed an increased incidence rate of 25-hydroxyvitamin D and zinc deficiency in newborns during the epidemic, implying that pregnant women should participate in appropriate physical exercise, increase their exposure to outdoor sunlight and improve nutrition intake to ensure healthy newborns during the quarantine period. Our study has provided some guidance for maternal management during the COVID-19 pandemic.
Highlights
In late December 2019, a pneumonia of unknown aetiology unprecedentedly broke out in Wuhan City, Hubei province in China [1]
There were no significant differences between the pandemic outbreak-period group and the early-stage outbreak group or the group of the same time frame in 2019 regarding age, body mass index (BMI), blood pressure or numbers of pregnancies and deliveries (Table 1, and Table S1)
Differences between the groups were compared with the Mann–Whitney U test, *p < 0.05, oral glucose tolerance test (OGTT): Oral glucose tolerance test
Summary
In late December 2019, a pneumonia of unknown aetiology unprecedentedly broke out in Wuhan City, Hubei province in China [1]. There were 118,817 confirmed cases and 5,533 total deaths in China [7]. Both COVID-19 and SARS belong to coronaviruses and can cause severe respiratory infections in people. In 2003, the highest incidence of SARS (12.5 cases per 100,000 people) occurred in Guangzhou city, China [8, 9]. The two earliest recorded COVID-19 cases occurred in Guangzhou on 22 January 2020 [10]. There have been 440 total confirmed cases, 354 discharged cases (15 cases imported overseas) and 1 death in Guangzhou through 31 March 2020 [11]
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