Abstract
Vitamin D deficiency in pregnant women may result in reduced neonatal development due to the fact that systemic vitamin D status during fetal life depends on maternal concentrations. Some authors reported significant differences in neonatal anthropometric measurements depending on maternal vitamin D concentrations. The aim of this study is to evaluate the relationship between maternal and cord blood concentrations of vitamin D and neonatal anthropometric measurements at birth. This study included 94 pregnant women, at term, who delivered at the Department of Obstetrics, Women's Diseases and Gynecological Oncology, Medical University of Warsaw. Total serum 25(OH)D concentration was measured in mother-child pairs, and newborn anthropometric data were collected. A multiple regression analysis was used for statistical analysis. No relationship between maternal and neonatal cord blood vitamin D concentrations vs. neonatal weight, length, head, and chest circumference at birth was found (p > 0.05). Severe vitamin D deficiency (<10 ng/ml) was detected in 10.6%, deficiency (10-20 ng/ml) in 39.4%, insufficiency (20-30 ng/ml) in 39.4%, and optimal vitamin D concentration (>30 ng/ml) only in 10.6% of the pregnant women. Cord blood vitamin D deficiency (<20 ng/ml) was found in 28.7% of the neonates. No differences between neonatal anthropometric measurements of infants born to mothers with normal and deficient vitamin D concentrations were found.
Highlights
Vitamin D is responsible for a number of important functions in the fetus, and vitamin D blood saturation in the neonate is directly dependent on maternal levels
The aim of this study is to evaluate the relationship between maternal and cord blood vitamin D concentrations and the anthropometric parameters of the newborn as well as the Apgar score
No statistically significant differences were found between neonatal anthropometric parameters in the winter and summer groups vitamin D concentrations were higher in the summer compared to the winter group [mean, 22.2 ± 6.5 ng/ml vs. 16.3 ± 8.0 ng/ml (p = 0.0003) for the mothers and 31.3 ± 9.4 ng/ml vs. 22.0 ± 11.0 ng/ml (p = 0.0001) for the neonates]
Summary
Vitamin D is responsible for a number of important functions in the fetus, and vitamin D blood saturation in the neonate is directly dependent on maternal levels. The contemporary lower reference range for cord blood vitamin D level is 20 ng/ml [1, 22]. The literature reports unanimously agree that cord blood serum concentration of vitamin D is directly correlated with maternal levels. Regardless, cord levels may be higher [24, 27,28,29], equal to [12, 14, 19], and lower than maternal venous vitamin D concentration [30, 31]. Neonates born to mothers with adequate vitamin D concentrations during pregnancy are supplied until 8 weeks of life [2, 32]. The contemporary literature questions whether the dose of vitamin D routinely administered to all newborns in the first weeks after birth should depend on the maternal concentrations and infant weight [3, 23]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
