Abstract
The ultrastructure of neurons and interneuronal connections in sensorimotor cortex have been studied in the offspring at 14- and 21-day-old female rats damaged by alcohol intoxication before pregnancy. We found three categories of ultrastructural changes in cortical neurons and interneuronal connections: delayed maturation of these structures, dystrophic and destructive changes and a signs of compensatory-adaptive processes. The first two categories of neuronal changes more marked at 14 days after birth. Later compensatory-adaptive changes become more significant, but dystrophic and destructive neuronal changes still remained. It is believed, that prenatal hypoxia-ischemia following alcohol consumption by female rats before pregnancy plays an important role in the pathogenesis of alcohol damage in cortical neurons and interneuronal connections in the offspring.
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