Maternal air pollution exposure & adverse neonatal outcomes. Protocol of a scope review

Abstract

IntroductionInfant mortality, low birth weight, impaired lung development, later respiratory morbidity & alterations in immune development were associated wirh maternal air pollution exposure. Consecuense of these pregnancy outcomes are increased risk of death in the first month of life, growth retardation, lower IQ & metabolic diseases in adulthood in evidence from China & Australia. Frequency of reported outcomes & the nature, type or extent of evidence in the rest of the world on adverse neonatal outcomes is unclear.ObjectiveTo assess the nature, type & extent of evidence related to maternal air pollution exposure & adverse neonatal outcomesMethodologyScoping Literature Review will be conducted. Complete protocol was developed & is avaibable upon request. We search in MEDLINE, EMBASE, Scopus, Virtual Health Library PAHO & Google Scholar. We search for all research designs describing maternal air pollution exposure & adverse neonatal outcomes. At least two independent reviewers screen titles & abstracts according to inclusión criteria. Data extraction phase will be carry on a form. No risk of bias assessment will be performed. Search strategies will be reported, including number of references examined, duplicates removed, & full text papers reviewed according to PRISMA-P extention for Scoping. Results will be presented as a "map" of the data in the form of diagrams & tables, including Investigator, year, Country,Date, Objetive, Epidemiological design, Analysis, Population characteristics, Outcomes. We will use Rayyan & Colab interactive environment to support self-learning projects, data analysis.Results We get almost 9800 articles, full text reviewed 9200 & extracted information according forms. Most frequent outcomes include LBW then were grouped by pollutant agent & outcome.Social ImpactThis Scoping Literature Review will help identifying existing evidence related to maternal air pollution exposure & adverse neonatal outcomes suggesting potential modifiable factors to reduce adverse events after prove effectiveness through research hypotheses.