Abstract
Polyether ether ketone (PEEK) is a biocompatible alternative to metallic biomaterials because of its unique properties and biocompatibility. Its bioinert nature may lead to implant failure from inadequate osseointegration. Therefore, this research aims to develop the nSiO2 ceramic particle-reinforced PEEK (nSiO2@PEEK) polymer nanocomposite. The particle size of nanoparticles was measured as 43.6 nm using the particle size analyzer (PSA). The morphology of the fabricated composite was analyzed using FESEM. The structural characteristic of nSiO2@PEEK was investigated using XRD and FTIR. Thermal stability was examined using TGA thermograms and DSC curves. Minimum toxic level (grade: slight, 1–20%) was observed by in vitro cytotoxicity assessment using direct and indirect methods. Excellent cell viability was found as 83.6% through MTT assay. The MG-63 cell adhesion study was conducted subsequently excellent cell growth and cell morphology were monitored using SEM analysis. This investigation found the nanocomposite to be biocompatible. It is a promising biomaterial for medical implants.
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