Abstract
BackgroundVentricle material properties are difficult to obtain under in vivo conditions and are not readily available in the current literature. It is also desirable to have an initial determination if a patient had an infarction based on echo data before more expensive examinations are recommended. A noninvasive echo-based modeling approach and a predictive method were introduced to determine left ventricle material parameters and differentiate patients with recent myocardial infarction (MI) from those without.MethodsEcho data were obtained from 10 patients, 5 with MI (Infarct Group) and 5 without (Non-Infarcted Group). Echo-based patient-specific computational left ventricle (LV) models were constructed to quantify LV material properties. All patients were treated equally in the modeling process without using MI information. Systolic and diastolic material parameter values in the Mooney-Rivlin models were adjusted to match echo volume data. The equivalent Young’s modulus (YM) values were obtained for each material stress–strain curve by linear fitting for easy comparison. Predictive logistic regression analysis was used to identify the best parameters for infract prediction.ResultsThe LV end-systole material stiffness (ES-YMf) was the best single predictor among the 12 individual parameters with an area under the receiver operating characteristic (ROC) curve of 0.9841. LV wall thickness (WT), material stiffness in fiber direction at end-systole (ES-YMf) and material stiffness variation (∆YMf) had positive correlations with LV ejection fraction with correlation coefficients r = 0.8125, 0.9495 and 0.9619, respectively. The best combination of parameters WT + ∆YMf was the best over-all predictor with an area under the ROC curve of 0.9951.ConclusionComputational modeling and material stiffness parameters may be used as a potential tool to suggest if a patient had infarction based on echo data. Large-scale clinical studies are needed to validate these preliminary findings.
Highlights
Ventricle material properties are difficult to obtain under in vivo conditions and are not readily available in the current literature
Xi et al presented a method for estimating diastolic mechanical parameters of the left ventricle (LV) from cine and tagged magnetic resonance imaging (MRI) measurements and LV cavity pressure recordings, separating the passive myocardial constitutive properties and diastolic residual active tension [22]
In vivo LV material stiffness determined by our models Human ventricle tissue material properties are extremely hard to quantify noninvasively under in vivo conditions
Summary
Ventricle material properties are difficult to obtain under in vivo conditions and are not readily available in the current literature. A noninvasive echo-based modeling approach and a predictive method were introduced to determine left ventricle material parameters and differentiate patients with recent myocardial infarction (MI) from those without. Determining ventricle tissue material properties and presence of myocardial infarction (MI) noninvasively based on in vivo image data are of great importance in clinical applications. By using magnetic resonance imaging (MRI) and finite element methods, Mojsejenko et al [20] estimated passive mechanical properties using a porcine infarct model. Xi et al presented a method for estimating diastolic mechanical parameters of the left ventricle (LV) from cine and tagged MRI measurements and LV cavity pressure recordings, separating the passive myocardial constitutive properties and diastolic residual active tension [22]
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