Abstract

Spectral/multienergy CT employing the state-of-the-art energy-discriminative photon-counting detector can identify absorption features in the multiple ranges of photon energies and has the potential to distinguish different materials based on K-edge characteristics. K-edge characteristics involve the sudden attenuation increase in the attenuation profile of a relatively high atomic number material. Hence, spectral CT can utilize material K-edge characteristics (sudden attenuation increase) to capture images in available energy bins (levels/windows) to distinguish different material components. In this paper, we propose an imaging model based on K-edge characteristics for maximum material discrimination with spectral CT. The wider the energy bin width is, the lower the noise level is, but the poorer the reconstructed image contrast is. Here, we introduce the contrast-to-noise ratio (CNR) criterion to optimize the energy bin width after the K-edge jump for the maximum CNR. In the simulation, we analyze the reconstructed image quality in different energy bins and demonstrate that our proposed optimization approach can maximize CNR between target region and background region in reconstructed image.

Highlights

  • X-ray computed tomography (CT) has been widely applied in clinical and preclinical applications, since Hounsfield’s Nobel Prize winning breakthrough

  • Different materials can be distinguished according to their K-edges characteristics [20, 21], while their Hounsfield numbers may be very similar in conventional CT images

  • Some relevant theories are similar, this study focuses on how to distinguish contrast agents and background materials in biomedical imaging with spectral CT, which can be readily generalized to deal with more general settings and able to determine the best energy bin for maximum material discrimination

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Summary

Introduction

X-ray computed tomography (CT) has been widely applied in clinical and preclinical applications, since Hounsfield’s Nobel Prize winning breakthrough. Spectral CT has a stronger capability to distinguish different materials because it can capture images in available energy bins [7,8,9,10,11,12,13]. K-edge characteristics involve the sudden attenuation increase in the attenuation profile of some contrast agents, which could be captured by spectral CT in available energy bins. Different materials can be distinguished according to their K-edges characteristics [20, 21], while their Hounsfield numbers may be very similar in conventional CT images. This opens a door for spectral CT to support functional, cellular, and molecular imaging studies

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