Abstract
Background. We are reporting on a case of platinum-refractory low-grade ovarian cancer responding to treatment with an allogeneic bone marrow transplantation from an unrelated donor. Case. The 37-year-old patient received a preparative regimen consisting of fludarabine 25 mg/m 2 on days −6, −5, −4, −3 and −2, melphalan 70 mg/m 2 on days −3 and −2, and thymoglobulin 2 mg/kg on days −3, −2 and −1. An unrelated HLA-compatible bone marrow was infused on day 0. Graft-versus-host disease prophylaxis consisted of tacrolimus and methotrexate. The patient demonstrated complete donor chimerism. Serial CT scans of the abdomen and pelvis over the following 15 months showed a slow regression of the malignant lesion. Conclusion. Engraftment of an unrelated donor marrow was achieved in a patient with ovarian cancer and induced a tumor response. This suggests the presence of a graft-versus-tumor effect in ovarian cancer. Further study is underway.
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