Abstract
Master Slave optical coherence tomography (MS-OCT) is an OCT method that does not require resampling of data and can be used to deliver en-face images from several depths simultaneously. As the MS-OCT method requires important computational resources, the number of multiple depth en-face images that can be produced in real-time is limited. Here, we demonstrate progress in taking advantage of the parallel processing feature of the MS-OCT technology. Harnessing the capabilities of graphics processing units (GPU)s, information from 384 depth positions is acquired in one raster with real time display of up to 40 en-face OCT images. These exhibit comparable resolution and sensitivity to the images produced using the conventional Fourier domain based method. The GPU facilitates versatile real time selection of parameters, such as the depth positions of the 40 images out of the set of 384 depth locations, as well as their axial resolution. In each updated displayed frame, in parallel with the 40 en-face OCT images, a scanning laser ophthalmoscopy (SLO) lookalike image is presented together with two B-scan OCT images oriented along rectangular directions. The thickness of the SLO lookalike image is dynamically determined by the choice of number of en-face OCT images displayed in the frame and the choice of differential axial distance between them.
Highlights
Before the optical coherence tomography (OCT) advent, the most commonly used imaging modalities in ophthalmology based on retinal fundus imaging via a camera [1] and on laser scanning ophthalmoscopy (SLO) [2], delivered images with en-face orientation
The other en-face images are collected from depths separated by 21 μm, the last en-face image is collected from z = 2.415 mm
A quasi real-time master slave (MS) based OCT/SLO instrument is demonstrated, by harnessing the graphics processing units (GPU) capabilities to employ the potential of the MS technology in terms of its parallelization
Summary
Before the optical coherence tomography (OCT) advent, the most commonly used imaging modalities in ophthalmology based on retinal fundus imaging via a camera [1] and on laser scanning ophthalmoscopy (SLO) [2], delivered images with en-face orientation These two traditional retinal imaging modalities can generate excellent quality images but with limited axial resolution. Attempts were made to increase the number of en-face images, such as using a low-coherence interferometer configuration, equipped in each arm with an adjustable optical path length ring [7] Using this idea, simultaneous en-face OCT imaging with sufficient good signal to noise ratio could be performed from 5 different depths only in a Drosophila melanogaster fly
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