Abstract
To better understand the origins of hepatitis delta virus (HDV), Perez-Vargaset al. sought to characterize the capability of HDV in utilizing envelope glycoproteins from viruses other than hepatitis B virus (HBV)(1). To this end, the authors compared the efficiency of HDV assembly and release in the presence of HBV surface antigens (HBsAg), vesicular stomatitis virus (VSV) G protein, or hepatitis C virus (HCV) E1 and E2 glycoproteins. The HDV particles generated with these respective glycoproteins were infectious to cells displaying appropriate receptorsin vitro. HDV incorporation of VSV-G or HCV-E1E2 wasassisted by farnesylation of the large hepatitis delta antigen (HDAg-L), a mechanism also seen withHBsAg. This article is protected by copyright. All rights reserved.
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