Abstract
(Immunity 35, 550–561; October 28, 2011) In this article, Figures 1B and 1C were switched, as were Figures 5B and 5C . The corrected figures are shown here. The corresponding legends and citations in the article are correct as is. Additionally, the name of author Carla Ortiz appeared incorrectly as Carla Oliva. This has been corrected in the author list as shown. The authors deeply regret this oversight.Figure 5GM-CSF Is Required for Tolerance by Inducing Prosurvival Genes in Graft-Derived DCsView Large Image Figure ViewerDownload Hi-res image Download (PPT) Mast Cells Condition Dendritic Cells to Mediate Allograft Tolerancede Vries et al.ImmunityOctober 28, 2011In BriefPeripheral tolerance orchestrated by regulatory T cells, dendritic cells (DCs), and mast cells (MCs) has been studied in several models including skin allograft tolerance. We now define a role for MCs in controlling DC behavior (“conditioning”) to facilitate tolerance. Under tolerant conditions, we show that MCs mediated a marked increase in tumor necrosis factor (TNFα)-dependent accumulation of graft-derived DCs in the dLN compared to nontolerant conditions. This increase of DCs in the dLN is due to the local production of granulocyte macrophage colony-stimulating factor (GM-CSF) by MCs that induces a survival advantage of graft-derived DCs. Full-Text PDF Open Archive
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