Abstract
The correlation between microvessel density and mast cells density in canine mammary tumors was studied. Sixty-five samples of canine mammary tumors, being 24 benign and 41 malignant, were analyzed. The routine Toluidine Blue staining method was used to assess the mast cells. To evaluate angiogenesis, the immunohistochemical expression of CD31 was assessed. There was no significant difference in either mast cells (P=0.44) or microvessel density (P=0.77) between malignant and benign tumors. A positive correlation was observed between microvessel density and mast cells (r=0.39; P=0.011) in malignant tumors. These results suggest that mast cells may play a role in canine mammary malignant tumors development, promoting angiogenesis, similar to some tumors described in the human species
Highlights
Mammary tumors are among the most common neoplasms in women and female dogs (Dutra et al, 2004)
Human medicine for several solid tumors (Imada et al, 2000; Elpek et al, 2001; Ribatti et al, 2004, Paoloni and Khanna, 2008). Inflammatory cells such as macrophages, neutrophils, lymphocytes, and mast cells contribute to tumor angiogenesis by releasing potent angiogenic factors stored in their cytoplasm (Ribatti et al, 2004)
There was no significant difference in either mast cells (P=0.44) or microvessel density (P=0.77) counting, comparing malignant versus benign tumors (Table 1)
Summary
Mammary tumors are among the most common neoplasms in women and female dogs (Dutra et al, 2004). Spontaneous mammary tumors in bitches have been proposed as comparative animal models for the study of mammary neoplasms. They can be used to evaluate new therapeutic strategies, prognostic, and predictive factors (Paoloni and Khanna, 2008). Human medicine for several solid tumors (Imada et al, 2000; Elpek et al, 2001; Ribatti et al, 2004, Paoloni and Khanna, 2008) Inflammatory cells such as macrophages, neutrophils, lymphocytes, and mast cells contribute to tumor angiogenesis by releasing potent angiogenic factors stored in their cytoplasm (Ribatti et al, 2004). According to Ranieri et al (2003), there is a mutual stimulus among tumor cells, inflammatory cells, and endothelial cells by paracrine mechanisms that result in more intense angiogenesis, tumor development, and dissemination
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Arquivo Brasileiro de Medicina Veterinária e Zootecnia
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
