Abstract
Cutaneous leishmaniasis is a parasitic skin disease with ∼1 million new cases and about 30,000 annual deaths (Sacks and Noben-Trauth, 2002). During blood feeding, sand flies inoculate parasites into host skin where they are ingested by phagocytes such as macrophages or neutrophils. Later, intracellular life forms of the parasites are ingested by dendritic cells, which then migrate to draining lymph nodes and release IL-12p40. This in turn activates IFNγ-producing CD8+ Tc1 and CD4+ T helper (Th) 1 T cells, enabling infected macrophages to kill intracellular parasites (Sacks and Noben-Trauth, 2002).
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