Abstract
These were 2 patients with heterozygous SCD with highly abundant macroscopic hematuria. The patients were 23 and 31 and had a clotting total hematuria. They were both anemic with good renal function. Cystoscopy had found bleeding from the left kidney in both patients. Uro-tomodensitometry and diagnostic uretero-renoscopy were without particularity for both patients. Treatment consisted of transfusions, oral rehydration, and hydergine for vaso-occlusive crisis.
Highlights
Hematuria in patient with sickle cell disease (SCD) results from microthrombotic infarction in the vasa recta and peritubular capillaries of the renal medullar, with extravasation of blood in the collecting tubes.Case description: These were 2 patients with heterozygous SCD with highly abundant macroscopic hematuria
What is particular in the SCD is that it results from micro-thrombotic infarctions in the vasa recta and peritubular capillaries of the renal medulla, with extravasation of blood in the collecting tubes
The origin of the bleeding can be bilateral, but the left kidney is most often involved. This predominance is due to an anatomical difference, since the left renal vein is longer than the right, which leads to an increase in venous pressure on the left side [1]
Summary
Hematuria in patient with sickle cell disease (SCD) results from microthrombotic infarction in the vasa recta and peritubular capillaries of the renal medullar, with extravasation of blood in the collecting tubes.Case description: These were 2 patients with heterozygous SCD with highly abundant macroscopic hematuria. Hematuria in patient with sickle cell disease (SCD) results from microthrombotic infarction in the vasa recta and peritubular capillaries of the renal medullar, with extravasation of blood in the collecting tubes. The presence of red blood cells in the urine is linked to a lesion of the parenchyma or the urinary tract. This leads to the (micro or macroscopic) invasion of blood vessels, the contents of which will come into contact with the lumen of the urinary excretory tract [1]. What is particular in the SCD is that it results from micro-thrombotic infarctions in the vasa recta and peritubular capillaries of the renal medulla, with extravasation of blood in the collecting tubes.
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