Abstract
The study of mass transport processes across synthetic and biological interfaces has increased in near-exponential fashion in the recent past. Originally, we considered writing a general review of information accumulated in the field during the past three years, but the scope of such a narrative would have permitted, at best, superfi cial summary of well over 3000 articles. Even a cursory treatment of recent develop ments in renal tubular physiology, an issue of major interest to workers in this laboratory, would have exceeded by far the space allotted to us in this volume. Consequently, we restricted the scope of this review to an examination of the effects of antidiuretic hormone (ADH) on nonelectrolyte permeation, Na+ transport, and water flows in hormone-sensitive epithelia. There are other cogent reasons for such a choice. The effects of ADH on transport processes in epithelia have been and continue to be a widely cited and extensively studied set of physiological events. The elegant dual-barrier hypothesis proposed originally by Andersen & Ussing (2), and subse quently by Leaf & Hays (Ito, III, 148), has provided a formidable frame of reference for rationalizing in a unitary fashion the effects of ADH on transport phenomena in amphibian epithelia. It is clear that understanding the physiological effects of ADH on renal tubular epithelia will form the basis for analyzing the
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