Abstract
Mass Spectrometry: Reconnaissance at the Frontiers of Biology
Highlights
The 10th International Symposium on Mass Spectrometry in the Health and Life Sciences: Molecular and Cellular Proteomics was held in San Francisco in August 2011
The articles contained in this special issue of Molecular & Cellular Proteomics are a representative sampling of the presentations and illustrate both the technical advances and the practical applications of mass spectrometry to proteomic analyses in the past 2 years
Three articles describe improved developments with existing methodology, as it relates to quantification of both proteins and post-translational modifications: Deeb et al, 77– 89 [Mann] used super-SILAC for the classification of diffuse large B-cell lymphoma subtypes, Stokes et al, 187–201 [Silva] describe the identification and quantification of peptides from critical signaling proteins by immunoaffinity enrichment coupled with LC-MS/MS (PTMScan Direct), and Peach et al, 128 –137 [Jaffe] illustrate the use of chromatin immunoprecipitation-grade antibodies in the quantitative assessment of histone modifications
Summary
Three articles (presenters at the meeting are indicated by brackets) describe improved developments with existing methodology, as it relates to quantification of both proteins and post-translational modifications: Deeb et al, 77– 89 [Mann] used super-SILAC for the classification of diffuse large B-cell lymphoma subtypes, Stokes et al, 187–201 [Silva] describe the identification and quantification of peptides from critical signaling proteins by immunoaffinity enrichment coupled with LC-MS/MS (PTMScan Direct), and Peach et al, 128 –137 [Jaffe] illustrate the use of chromatin immunoprecipitation-grade antibodies in the quantitative assessment of histone modifications. The 10th International Symposium on Mass Spectrometry in the Health and Life Sciences: Molecular and Cellular Proteomics was held in San Francisco in August 2011.
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