Abstract
A new instrument based on VUV laser desorption/ionization (VUVDI) method was used to measure the mass spectrum of the cholesterol standard and the mass spectrometry images (MSI) of intact cholesterol in a mouse esophagus tissue section and mouse zygotes. The VUVDI mass spectrum of the cholesterol standard shows dominant peaks from the parent molecules. In the case of the mouse esophagus tissue section, the ion images with a lateral resolution of ∼ 4 μm reveal that the cholesterol populates mainly in the mucosae. The experimental results indicate that the VUVDI method may provide a new MSI tool to measure the intact cholesterol in tissues and cells.
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