Abstract
Dried blood spot sampling technique has been a prevalent approach in therapeutic drug monitoring due to its numerous advantages over conventional blood or plasma sampling. But the effects of storage conditions, drying time in air and paper substrates on the stability and analysis sensitivity of therapeutic drugs are still lack. Herein we systematically investigated the effects of storage conditions and paper substrates on the appearance of dried blood spots and stability of different therapeutic drugs by using a facile paper spray mass spectrometry. The results demonstrated using silica coated paper SG81 favored to get an abundant signal due to the unique elution behavior of target compounds in dried blood spots relative to that with grade ET31 and grade 1 paper substrates. By examining the effects of light illumination and air on the stability of therapeutic drug, it reveals that both have a similar impact on the degradation of the tested drugs, whereas storing the samples in a zip-foiled bag could effectively suppress the degradation of the analytes in dried blood. The analysis sensitivity of different drugs in blood samples was also compared under different storage conditions. An improvement of 2–10-fold analysis sensitivity was obtained for these drugs when the DBS were stored in a zip-foiled bag relative to that exposure to air.
Published Version
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