Abstract
Open AccessArticle Mass Spectra of 2-Substituted Diethyl Malonate Derivatives by Tae Woo Kwon 1,*, Sung Kee Chung 2 and Michael B. Smith 3 1 Department of Chemistry, KyungSung University, Pusan 608-736, Korea 2 Department of Chemistry, Pohang Institute of Science and Technology, Pohang, Korea 3 Department of Chemistry, U-60, Rm. 151, 215 Glenbrook Rd. University of Connecticut, Storrs, Connecticut, 06269-4060, USA * Author to whom correspondence should be addressed. Molecules 1999, 4(3), 62-68; https://doi.org/10.3390/40300062 Received: 16 March 1998 / Accepted: 10 July 1998 / Published: 16 March 1999 View Full-Text Download PDF Browse Figures Citation Export BibTeX EndNote RIS Cite This Paper
Highlights
Diethyl ethoxymethylene malonate (EMME) is an extremely valuable starting material for the synthesis of quinolones [1]
There have been reports of the conversion of EMME to benzo[b]quinolizines via reaction with oxoquinolinyl acetates [5], and into pyrido[2,3-d]pyrimidines by reaction with oxopyrimidines [6]. In contrast to these previous reports, we have found that the Molecules 1999, 4 reaction of EMME and Grignard regents or organocuprates gives symmetric malonates 1-4, or asymmetric malonate derivatives 5-6 in moderate yield
We report the electron impact mass spectra of 1-6, recorded at 70 eV
Summary
Diethyl ethoxymethylene malonate (EMME) is an extremely valuable starting material for the synthesis of quinolones [1]. Abstract: Addition of Grignard derivatives to diethyl ethoxymethylene malonate generates In contrast to these previous reports, we have found that the Molecules 1999, 4 reaction of EMME and Grignard regents or organocuprates gives symmetric malonates 1-4, or asymmetric malonate derivatives 5-6 in moderate yield. This is in contrast to the asymmetric phenyl malonate (5) and the n-butyl derivative (6), which gave no apparent molecular ions.
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