Abstract
POEMS syndrome is a paraneoplastic disorder characterized, among other things, by low clonal plasma cell burden, peripheral neuropathy and high VEGF levels. Plasma cell directed therapies and radiation of solitary bone lesions have been associated with long term clinical responses even in patients without a hematologic response. This suggests that current therapies might act through non-specific immunomodulation. In this study we sought to identify mechanisms of disease development by comparing the immune tumor microenvironment (iTME) of patients with POEMS syndrome to that of patients with MGUS.
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