Abstract

Planning for major incidents involving the release of hazardous chemicals has been informed by a multi-disciplinary research agenda which has sought to inform all aspects of emergency response, but with a focus in recent years on mass casualty decontamination. In vitro and human volunteer studies have established the relative effectiveness of different decontamination protocols for a range of chemical agents. In parallel, a programme of research has focused on communicating with and managing large numbers of contaminated casualties at the scene of an incident. We present an accessible overview of the evidence underpinning current casualty decontamination strategies. We highlight where research outcomes can directly inform response planning, including the critical importance of beginning the decontamination process as soon as possible, the benefits of early removal of contaminated clothing, the evidence under-pinning dry and wet decontamination and how effective communication is essential to any decontamination response. We identify a range of priority areas for future research including establishing the significance of the ‘wash-in’ effect and developing effective strategies for the decontamination of hair. We also highlight several areas of future methodological development, such as the need for novel chemical simulants. Whilst considerable progress has been made towards incorporating research outcomes into operational policy and practice, we outline how this developing evidence-base might be used to inform future iterations of mass casualty decontamination guidance.

Highlights

  • The global development, distribution and use of chemicals continues to increase annually, with thousands, including toxic industrial chemicals, being manufactured and distributed in excess of one metric tonne annually [1]

  • The study thatmethod the number of white-roll sheets used dry denation is nowfound the default of decontamination forduring non-caustic contamination was significantly associated with lower total recovery of MeS from the skin with on average three times less simulant recovered from volunteers that used 10 sheets or more compared to those that used less than 10 sheets [41]

  • Decontamination efficacy can be influenced by a multitude of factors including the number of exposed persons, the properties of the chemical agent, the speed of the response and the effectiveness of casualty and first responder communication and management

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Summary

Introduction

The global development, distribution and use of chemicals continues to increase annually, with thousands, including toxic industrial chemicals, being manufactured and distributed in excess of one metric tonne annually [1]. The primary public health concern following a chemical incident will be to preserve life To this end, the decontamination of exposed persons, defined as any action that reduces, removes, neutralizes or inactivates contamination is an immediate consideration. Following chemical incidents in the UK, first responders have historically been instructed to stand-off and wait for specialist Fire and Rescue Services (FRS) capability including mass-decontamination units (MDUs) to arrive at the scene. This approach introduces a time delay that is especially detrimental to persons exposed to rapidly acting hazardous chemicals. We discuss considerable knowledge gaps that should be prioritized as future research needs

Key Findings from Mass Casualty Decontamination Research
Speed Is Critical
The Importance of Disrobing
There Are Optimised Parameters for Mass Decontamination Showering
Decontamination Methods Have Variable Efficacy for Liquid Contaminated Hair
Decontamination Must Be Casualty Focused to Facilitate Compliance
Future Research Priorities
The Choice of Chemical Simulant for Human Volunteer Studies
Accurately Assessing Systemic Exposure
The Significance of the ‘Wash-In’ Effect
Improved Communication Strategies
Findings
Conclusions
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