Masked-hemolysis as novel cause of hepatic iron overload in ALD

Abstract

Patients with alcoholic liver disease (ALD) develop prognostically unfavourable hepatic iron overload (HIO) and anemia, however, the underlying molecular mechanisms and the role of the systemic iron masterswitch hepcidin are poorly understood. Herein, we identify hemolysis as novel factor in disrupting hepcidin regulation and causing HIO.