MASE-sLASER, a short-TE, matched chemical shift displacement error sequence for single-voxel spectroscopy at ultrahigh field.

Abstract

B1 inhomogeneity and chemical shift displacement error (CSDE) increase with the main magnetic field strength and are therefore deleterious for magnetic resonance spectroscopy (MRS) at ultrahigh field. A solution is to use adiabatic pulses which operate over a broad range of B1 and thus are insensitive to B1 inhomogeneity. Moreover, adiabatic pulses usually have a relatively higher bandwidth, which makes CSDE low to negligible. The use of exclusively adiabatic pulses for single-voxel spectroscopy (SVS) typically brings the disadvantage of a long echo time (TE), but the advantage of a low and matched CSDE. Herein, we took advantage of short-duration, low-power, matched-phase adiabatic spin echo (MASE) pulses to implement a matched CSDE semi-localized by adiabatic selective refocusing (sLASER) sequence capable of attaining short TEs, while CSDE is matched and still comparatively low. We also demonstrate here the feasibility of the direct measurement of the γ-aminobutyric acid (GABA) resonance at 2.28ppm well separated from the neighboring glutamate resonance at 7T using the implemented MASE-sLASER sequence at TEs of 68 and 136ms. The shorter duration of MASE pulses also made it possible to implement a Mescher-Garwood-semi-localized by adiabatic selective refocusing (MEGA-sLASER) (with MASE) sequence with TE=68ms for editing GABA at 7T, the results for which are also shown.