Abstract
THE CLINICAL PICTURE associated with neoplasm of the cortex of the adrenal glands may vary as widely as the physiologic processes in which that structure plays a part. Cushing’s basophilism, masculinization, feminization, Addison’s disease, simple malignant cachexia and renal syndromes, may each or all result from new growths, the histologic features of which are not strikingly or gratifyingly distinctive. Experimental work on normal animals has far outdistanced clinical analysis and conclusion. It is with the hope of adding more clinical data for which logical associations can be made that 3 cases of cancer of the cortex of the adrenal gland, with masculinization, and 3 without secondary sexual changes are reported. Case 1. E. T., a 34-year-old white female, 5 ft., 3 in. tall, was admitted to the hospital complaining of weakness, dyspnea on exertion, and slight ankle edema during the preceding year.
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