Abstract
Rotaviruses are the leading cause of gastroenteritis in young children. The incidence of diarrhea due to rotavirus in Indonesia is evenly throughout the year with the mortality approximately of 10,088 children in a year. These viruses are transmitted by fecal-oral route with high rate of transmission. More than 50 combinations G-P known as strain that infect human with the predominant serotypes will vary between region and year. In Indonesia, rotavirus studies showed that a variety of VP7 type (G9) and VP4 type (P[8]) were the genotype combinations most frequently encountered. The most likely methods of prevention and control of transmission for the disease caused by this virus are vaccination. Various types of rotavirus vaccine were developed to provide the best immunity as the natural infection and minimize the side effects that might be occurred. For that oversight both pre and post licensing is required to monitor the side effects of the existing vaccine. Since the rotavirus infections cause high disease and economic burden, the vaccine can be considered as one of the better ways of prevention.
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