Abstract
Metabotropic glutamate receptors (mGluRs) are an important family of class C G protein-coupled receptors (GPCRs) characterized by a large extracellular ligand-binding domain (LBD) and a constitutive dimeric arrangement in the cell membrane. While the role of inter-LBD conformational dynamics in mGluR dimerization and activation has been extensively studied, the contribution of the transmembrane domains (TMDs) has only recently been explored using single molecule subunit counting experiments and inter-TMD fluorescence resonance energy transfer (FRET) measurements in living cells.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
