Abstract
Cell Biology The kinases of the MARK family are involved in specifying cell polarity. Sandi et al. found that phosphorylation of Ser151 in the cytoskeleton-associated protein ARHGEF2 by MARK3 caused ARHGEF2 to dissociate from microtubules and activate RhoA. As a result, the actin cytoskeleton in cultured cells was remodeled to form three-dimensional structures. Thus, the phosphorylation state of Ser151 of ARHGEF2 determines whether it is sequestered by the tubulin cytoskeleton or released to remodel the actin cytoskeleton and regulate cell polarity. Sci. Signal. 10 , eaan3286 (2017).
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Paper version not known
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
