Abstract
5114 Background: Granulosa cell tumors are rare ovarian cancers that can be associated with significant morbidity and mortality. Little is known about prognostic markers of these tumors. We attempted to identify some of the molecular markers that can be used to determine candidates for postoperative chemotherapy to prevent recurrence. Methods: 33 cases were retrieved from the files of Yale Tumor Registry over a period of 12 years from 1992 to 2003. The patients ranged from 6 to 84 years of age, with a median age of 51 years. Conventional prognostic factors (age, tumor size, mitotic activity, capsular invasion and histologic pattern) were assessed. Morphological assessment identified 3 juvenile type, and 30 adult type tumors. A total of 9 cases with metastatic or recurrent disease were identified. A few novel markers were evaluated in the tumors with and without recurrence as well as in the recurrent and metastatic tumors. Imunohistochemical staining for inhibin, cERB B4, ER beta, EGFR and Cyclin D2 was performed. The histological and morphological characteristics of the granulosa cell tumors with and without recurrence and/or metastasis were correlated with the immunohistochemical findings for possible association between the expression of a specific tumor immunoprofile or marker expression and tumor behavior. Results: Positive inhibin staining was obtained only in adult type of GCT, almost exclusively in the primary site, and correlated with more advanced age (>47 y.o.). We did not find a correlation between inhibin expression and tumor size. The mitotic index did not correlate with recurrence or inhibin staining. Conclusions: Current data suggests that inhibin could be a predictor for favorable tumor behavior. Testing tumor samples for cERB B4, cylin D2, EGFR may help to establish a stronger correlation between the presence of certain markers and tumor recurrence. No significant financial relationships to disclose.
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