MARKERS OF METABOLIC DISORDERS IN THE BLOOD OF SOWS IN CASE OF HEPATODYSTROPHY

Abstract

Liver diseases are widespread among pigs of different gender and age groups. Hepatodystrophy (hepatosis) is most often recorded among liver diseases. Various metabolic disorders develop in sows with hepatosis. Groups of sows of different ages (farrow number) with biochemical changes which are specific for hepatosis were formed in the conditions of the pig-breeding complex. In total, six groups of 5 sows in each were formed. The list of biochemical parameters allowed to assess the state of protein, lipid, carbohydrate, mineral and pigment metabolism, as well as activity of a number of enzymes. The diagnosis was confirmed by macro- and microscopic examination of the livers of sows. Macroscopic examination of the livers of sows with hepatosis revealed their increased size, rounded edges, variegated color. Similar changes were not found in the livers of healthy sows. Granular, vacuolar and fatty degeneration were found when studying histosections obtained from liver samples of sows with hepatosis. Derangements of protein and nitrogen metabolism (high levels of total protein and creatinine, decreased concentrations of albumin and urea, albumin-protein ratio) were found in sows with hepatosis. Derangements of carbohydrate and lipid (decrease of blood glucose, total cholesterol, triglycerides) and mineral metabolism (increase of concentration of iron and inorganic phosphorus with simultaneous decrease of concentration of calcium and calcium-phosphorus ratio) were noted. These changes of metabolic processes in the body are basically preconditioned by inhibition of synthetic function of the liver in case of hepatosis of sows.