Abstract
Markers of fluid responsiveness in hemodynamically unstable patients
Highlights
Unstable patients are often given intravenous (IV) crystalloids and colloids to increase cardiac output and improve tissue perfusion[1]
Fluid responsiveness was defined as an increase in cardiac output of at least 15% in 39 of 50 trials and at least 10% in the other 11 trials
An increase in cardiac output with passive leg raising had the strongest likelihood ratios for an indicator of fluid responsiveness, as did the presence of respiratory variation in vena cava diameter measured with ultrasound and pulse pressure variation in the subset of mechanically ventilated patients
Summary
Unstable patients are often given intravenous (IV) crystalloids and colloids to increase cardiac output and improve tissue perfusion[1]. The purpose of the systematic review summarized here is to provide summary estimates of the accuracy of the various symptoms, signs, and measurements used to predict fluid responsiveness in patients with refractory hypotension, signs of organ hypoperfusion, or both. In all studies indices were measured before assessment of fluid responsiveness.
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