Markers of Endothelial Injury and Dysfunction in Early- and Late-Onset Preeclampsia.

Jakub Kornacki,Ewa Wender-Ozegowska,Przemysław Wirstlein

doi:10.3390/life10100239

Jakub Kornacki, Ewa Wender-Ozegowska + Show 1 more

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https://doi.org/10.3390/life10100239

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Journal: Life	Publication Date: Oct 14, 2020
Citations: 12	License type: CC BY 4.0

Affiliation: Poznan University of Medical Sciences

Abstract

With regard to differences in the clinical symptoms of preeclampsia (PE), the degree of endothelial dysfunction may differ between early and late-onset preeclampsia (EOP and LOP). The authors of this study examined it by assessing the endothelial injury level in women with EOP (20 patients) and LOP (20 patients) and in normotensive pregnant women (20 patients) in their late second and third trimesters of pregnancy, using the two markers—the serum concentration of hyaluronan (HA) and the serum level of soluble vascular cell adhesion molecule-1 (sVCAM-1). The serum concentrations of HA and sVCAM-1 did not differ significantly between the EOP and LOP patients. However, these were statistically higher than that of the control group participants (p < 0.05; p < 0.001). A significant correlation between the levels of HA and sVCAM-1 was found both in the entire group of patients with preeclampsia (p = 0.0277) and in women with late-onset disease (p = 0.0364), but not in the patients with early-onset preeclampsia (p = 0.331). The obtained results indicated a comparable level of endothelial injury in the two types of PE. The presence of a similar degree of endothelial injury in patients with EOP and LOP should create awareness among all clinicians about the possible fatal complications in both groups of patients with PE.

Highlights

Preeclampsia (PE) is one of the most dangerous and mysterious complications of pregnancy with extremely complicated but partially known pathophysiology
A significant correlation between the levels of HA and soluble vascular cell adhesion molecule-1 (sVCAM-1) was found both in the entire group of patients with preeclampsia (p = 0.0277) and in women with late-onset disease (p = 0.0364), but not in the patients with early-onset preeclampsia (p = 0.331)
The obtained results indicated a comparable level of endothelial injury in the two types of PE

Summary

Introduction

Preeclampsia (PE) is one of the most dangerous and mysterious complications of pregnancy with extremely complicated but partially known pathophysiology It is a disease originating from the placenta, which affects the maternal endothelium, leading to its injury and dysfunction [1]. Researchers are intrigued by the differences in the clinical course of early- and late-onset preeclampsia (EOP and LOP), wherein patients with EOP exhibit a higher frequency of neurological, liver, and cardiorespiratory complications compared to those with LOP [2]. These differences may indicate the possible heterogeneity of PE with the two forms of the disease involving different pathophysiologies [3]. The endothelial injury level may vary between these disease types

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