Abstract
The aim of the work was to increase the effectiveness of treatment of the severe asthma phenotype in school-age children, taking into account the diagnostic value of atopic reactivity indicators. The study involved 30 pupils with severe asthma and 30 children with moderate-heavy version of it. Amid severe asthma increases risk of higher concentrations of IL-4 and IL-5 in the serum, and almost in every second child was observed the increased concentrations of Ig E (more than 545,3 IU/mL, odds ratio was 1,9 (95 % CI 1,1-3,4). In the group of patients with severe asthma were significantly more frequent cases of the skin hypersensitivity to household allergens with respect to the members of the second group. There were separated the indices of clinical and epidemiological risk and diagnostic value of some markers of atopic reactivity for verification of the severe asthma phenotype. It was established that the development of severe asthma in children marked tendency to reduce the metabolic activity of eosinophilic granulocytes in blood (in terms of intracellular content of cationic proteins and peroxidase) and phagocytic ability of these effector cells of allergic inflammation. For the phenotype of severe asthma the risk of high concentration of IL-4 and IL-5 in serum increased in 3,1 times, but this paraclinical test is rather suitable for verification of this phenotype (SP – 84,6% (95 % Sp 75,9–91,1)) than for its detection (Se – 36,4 % (95 % CI 26,9–46,6)).
Highlights
One of the most pressing problems of modern pediatric is allergic disease in children, including bronchial asthma (BA)
The aim was to increase the effectiveness of treatment of phenotype of the severe asthma in school-age children, taking into account the diagnostic value of atopic reactivity indicators
Since the development of asthma always associated with congenital, genetic determination hyper immunoglobulin E (IgE) [16, 18, 19], we studied its contents in serum of examined children
Summary
One of the most pressing problems of modern pediatric is allergic disease in children, including bronchial asthma (BA). Acute is the question of currently increasing the effectiveness of this disease therapy and achieve a level of control that would allow the child to lead an active social life. Imposing the controlling asthma therapy in children should be considered a feature of the phenotype, defined heterogeneous mechanisms of development, is almost identical clinical symptoms [3, 4]. Based on the above, taking into account the performance of atopic reactivity in children that reflect the specific pathogenic mechanisms of realization of asthma [5, 6], in a comprehensive study of patients will personalize the treatment of asthma and thereby improve treatment of the disease. The aim was to increase the effectiveness of treatment of phenotype of the severe asthma in school-age children, taking into account the diagnostic value of atopic reactivity indicators
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
