Markers Of Arrhythmia In Patients With Left Ventricular Outflow Tract Stenosis And Coartation Of Aort

Abstract

Objective: Arrhythmias due to congenital heart diseases are found to be the second most common cause of mortality after ischemic heart diseases in several studies . Coarctation of the aorta , hypertrophic cardiomyopathy and aort stenosis increase afterload of the left ventricle and as a result of this, they cause an increase in wall stress in the early and hypertophy of the wall in the late phase. This condition leads a corruption in ventricular and atrial conduction and predisposes to arrhythmias . In this study, we intended to examine the risks with indicators like P dis, QT dis, Tp-e for arrhythmias in diseases with left ventricular outflow tract stenosis in children. Method: 101 patients with with left ventricular outflow tract stenosis ( coarctation of the aorta, idiopathic hypertrophic subaortic stenosis , hypertrophic cardiomyopathy and aortic stenosis ) in pediatric age group who were diagnosed between 2008-2014 in Dr . Behçet Uz Children’s Training and Research Hospital were included in this study. 110 healthy children were included in this study as a control group. Pdis, corrected QT, QT dis ve Tp-e and Tp-e /QT indices in both groups were were calculated and compared using standard 12 -lead ECG. Results: P max, corrected QT, Pdis, QTdis, Tp-e and Tp-e/QT in patient group were found to be significantly higher than the control group . There was no difference between sub- groups of patient group according to Pmax, corrected QT, P dis, QT dis, Tp-e and Tp-e/QT. There was also no difference between beta blocker users and non-users according to P max, corrected QT, P dis, QT dis, Tp-e and Tp-e/QT. Conclusions: High P max, corrected QT, P dis, QT dis, Tp-e and Tp-e/QT in the patient group showed the risk for ventricular arrhythmias and atrial fibrillation in patients with left ventricular outflow tract stenosis .