Abstract
In 3 patients with hemophagocytic histiocytosis (HH) accompanied by disseminated intravascular coagulation syndrome (DIC) and multiple organ failure (MOF), a markedly significant decrease of plasma free protein S (PS) levels was found with markedly raised plasma C4b-binding protein (C4bp) levels as compared to non-HH DIC patients with MOF. Moreover, a significant elevation of serum cytokines, interleukin-lβ and tumor necrosis factorα, was observed when compared to non-HH DIC patients with MOF. Plasma free PS was inversely correlated with these two cytokines, while plasma C4bp was positively correlated with them.These results imply that abnormal plasma PS distribution, that is, markedly reduced free PS with raised C4bp-PS complex which was closely associated with hypercytokinemia would contribute to the pathogenesis of DIC and/or MOF in HH.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
