Abstract
Type 2 diabetes mellitus (T2DM) is often associated with hepatitis C virus (HCV) infection. Successful HCV treatment may improve glycemic control and potentially induce remission of T2DM. We report a case of an obese 52-year-old woman with mixed genotype 1a/1b HCV infection with compensated cirrhosis and a 10-year history of poorly controlled T2DM on insulin therapy. Following successful therapy with sofosbuvir, simeprevir, and ribavirin, her insulin requirements decreased and her glycosylated hemoglobin (HgA1c) normalized despite weight gain. This case suggests an association between HCV and T2DM and the potential for significant improvement in glycemic control with eradication of HCV.
Highlights
Type 2 diabetes mellitus (T2DM) is a common comorbid condition in approximately one-third of individuals with chronic hepatitis C virus (HCV) infection [1]
We report a case of mixed genotype 1a/1b HCV infection with compensated cirrhosis treated with direct acting antiviral agents (DAAs) resulting in significant improvement of poorly controlled T2DM despite increasing body mass index (BMI)
Many studies support an association between HCV infection and T2DM
Summary
Type 2 diabetes mellitus (T2DM) is a common comorbid condition in approximately one-third of individuals with chronic hepatitis C virus (HCV) infection [1]. Recent data suggest that HCV infection directly impairs glucose metabolism and contributes to insulin resistance [2]. Treatment of genotype 1 HCV infection with interferon based regimens or direct acting antiviral agents (DAAs) has correlated with improved insulin sensitivity and glycemic control in both insulin dependent and noninsulin dependent T2DM [3,4,5,6,7]. We report a case of mixed genotype 1a/1b HCV infection with compensated cirrhosis treated with DAAs resulting in significant improvement of poorly controlled T2DM despite increasing body mass index (BMI).
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
