Abstract
Serum levels of luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin, estradiol-17 beta and testosterone were determined in adult rats that were treated in the neonatal period with monosodium L-glutamate (MSG) which has previously been shown to reliably produce destruction of arcuate nucleus perikarya. MSG-treated males had significantly smaller accessory sexual organs (seminal vesicles and ventral prostate) and tests and had significantly lower serum concentrations of FSH and testosterone than sex-matched controls. MSG-treated females had significantly lower serum concentrations of LH, FSH and estradiol-17 beta. Prolactin levels of MSG-treated rats were no different than sex-matched controls. This marked reduction in gonadal steroid levels (decreases 68%) and inappropriately low gonadotropin levels further characterizes the deficit of feedback regulation in the hypothalamic-pituitary-gonadal axis in MSG-treated rats.
Highlights
Manganese exposure is known to cause a series of neurological sequelae in a variety of species
The stressful nature of the injection series was suggested by chronically elevated corticosterone and prolactin levels in saline-injected rats versus uninjected controls (Table 1)
No significant changes in neuropeptide levels were found in the striatum or frontal cortex after manganese treatment (Table 2)
Summary
Manganese exposure is known to cause a series of neurological sequelae in a variety of species. In man, these signs are characterized by a biphasic response. Symptoms similar to Parkinson's disease appear, including akinesia, rigidity, and tremor (Cook et al, 1974). These changes are paralleled by biochemical alterations of dopaminergic indices within the caudate nucleus (Cotzias et al, 1974), and this has led to attempted treatment of manganism toxicity with L-DOPA (Mena et al, 1970; Schunk, 1979). Behavioral dysfunction has been reported in rats (Roussel and Renaud, 1977) and mice (Chandra et al, 1979b)
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