Abstract
We have previously demonstrated that immunizing MHC inbred miniature swine with synthetic polymorphic peptides spanning the α1 domain of an allogeneic donor-derived swine leukocyte antigen class I gene leads to the accelerated acute and chronic rejection of class I disparate hearts. Here, we examine whether treating recipients with autologous immature dendritic cells (DCs) pulsed with synthetic class I peptides could down regulate an alloresponse.
Published Version
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