Abstract
Flare-up of allergic rhinitis has been implicated in worsening neuropsychiatric symptoms such as hyperactivity and anxiety in the general population, mostly supported by epidemiological data. However, it is unknown how such respiratory allergy symptoms affect behavioral symptoms in patients with intellectual disability and limited expressive language. These patients may express more severe behavioral symptoms partly due to frustration and anxiety, being under-diagnosed and undertreated secondary to a lack of proper communication means. Herein, we present two cases of patients with severely limited expressive language , in whom we observed marked improvement in behavioral symptoms and even cognitive activity following control of their symptoms of allergic rhinitis with the use of omalizmab, a humanized anti-IgE antibody. The presented cases indicate that clinicians need to be aware of profound effects of allergy rhinitis on neuropsychiatric symptoms in individuals with limited expressive language.
Highlights
The prevalence of immunoglobulin E (IgE)-mediated allergic diseases such as allergic rhinitis (AR) and atopic asthma is steadily rising in developed countries
In addition to the alarming increase of their prevalence, allergic diseases have begun to be recognized as an aggravating factor for neuropsychiatric conditions such as anxiety, obsessive–compulsive disorders (OCD), and attention deficiency hyperactivity disorders (ADHD)
This study presents 2 limited expressive language (LEL) cases of individuals suffering from severe aeroallergen allergy which required the second line allergy treatment, omalizmab
Summary
The prevalence of immunoglobulin E (IgE)-mediated allergic diseases such as allergic rhinitis (AR) and atopic asthma is steadily rising in developed countries. Timely diagnosis and treatment for allergic diseases can be important for controlling behavioral and neuropsychiatric symptoms in individuals with LEL. In these 2 subjects, omalizmab treatment resulted in marked improvement in their naso-ocular symptoms, and in the neuropsychiatric symptoms (especially difficult behaviors and cognitive activity), illustrating the profound effects of respiratory allergy in neuropsychiatric symptoms in subjects with LEL.
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