Abstract
e13598 Background: The present study was conducted to investigate the influence of marital status on survival of pure mucinous breast carcinoma(PMBC) based on surveillance, epidemiology, and end results (SEER) databases. Methods: Data were extracted from the SEER database on eligible patients diagnosed with pure mucinous breast carcinoma between 1998 and 2015. Patients were divided into married groups (including common law) and not married groups (including single[never married]/unmarried or domestic Partner、Divorced、Separated、Widowed). Survival curves were generated using the kaplan-meier method, and survival differences were estimated using the log-rank test. Multivariate Cox proportional risk models were used to assess independent risk factors for survival. Results: A total of 14972 eligible pure mucinous breast carcinoma patients were enrolled from the SEER database, including 7462(49.84%) married and 7510(50.16%) not married patients. The OS and CSS were significantly greater in married patients than not married patients (79.27 vs 62.49% for OS and 96.07 vs 93.34% for CSS, both P =0.000). Married patients were more likely to be more younger (aged≥75) (21.5% vs. 44.1%), cancer stage were even lower(stage I)(69.6% vs. 62.6%), (stage II)(28.6% vs. 33.9%), (stage III)(0.6% vs. 0.9%), (stage IV)(1.3% vs. 2.5%), more patients received breast conserving surgery(67.4% vs. 62.9%), chemotherapy(15.3% vs. 11.0%) and radiation therapy(54.3% vs. 43.1%), also no recurrent lymph node metastasis was observed(82.8% vs. 74.6%) compared to unmarried group(All P =0.000). The multivariate Cox proportional hazards model showed that marriage is an independent protective factor for OS (HR = 1.356, 95% CI: 1.271-1.446, P =0.000) and CSS (HR = 1.942, 95% CI: 1.681–2.644, P =0.000). Conclusions: Marital status was an independent prognostic indicator in PMBC patients. Research data showed that married pure mucinous breast carcinoma patients can obtain better OS and CSS than unmarried patients.
Highlights
The present study was conducted to investigate the influence of marital status on survival of pure mucinous breast carcinoma based on surveillance, epidemiology, and end results (SEER) databases
The Multivariate Cox Proportional Hazards Models showed that marriage is an independent protective factor for overall survival (OS) (HR =1.356, 95% confidence intervals (CI): 1.271-1.446, P= 0.000) and cancer-specific survival (CSS) (HR =1.942, 95% CI: 1.681–2.644, P= 0.000)
Based on the inclusion criteria, we identified a total of 14972 patients with Pure mucinous breast carcinoma (PMBC) diagnosed between 1998 and 2015 in the SEER database
Summary
The present study was conducted to investigate the influence of marital status on survival of pure mucinous breast carcinoma based on surveillance, epidemiology, and end results (SEER) databases. Pure mucinous breast carcinoma(PMBC), known as colloid carcinoma, is a rare malignancy of the breast. Rosen[6]developed diagnostic criteria of PMBC that lesions could not display high-grade histological features and with tumors composed of at least 90% mucin[7]. The population of patients with PMBC is mostly postmenopausal women, showing good clinical pathological characteristics, including lower incidence of lymph node metastasis, higher expression of estrogen and progesterone receptor (PR), and better cancer differentiation[8,9]. PMBC was defined as a slow-growing tumor, for which the prognosis is somewhat better than that for MC and infiltrating ductal carcinoma (IDC)[10,11,12]
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