Abstract
BackgroundMarital status proves to be an independent prognostic factor in a variety of cancers. However, its prognostic impact on gastric neuroendocrine neoplasms (G-NEN) has not been investigated.MethodsWe identified 3947 G-NEN patients from the Surveillance, Epidemiology, and End Results (SEER) database. Meanwhile, propensity scores for marital status were used to match 506 unmarried patients with 506 married patients. We used Kaplan–Meier method and multivariate Cox regression to analyse the association between marital status and the overall survival (OS) and G-NEN cause-specific survival (CSS) before matching and after matching.ResultsMarried patients enjoyed better OS and CSS, compared with divorced/separated, single, and widowed patients. Multivariate Cox regression analysis indicated that unmarried status was associated with higher mortality hazards for both OS and CSS among G-NEN patients. Additionally, widowed individuals had the highest risks of overall (adjusted hazard ratio (HR): 1.56, 95% confidence interval (CI): 1.35–1.81, P < 0.001) and cancer-specific mortality (adjusted HR: 1.33, 95% CI: 1.05–1.68, P = 0.02) compared to other unmarried groups in both males and females. Furthermore, unmarried status remained an independent prognostic and risk factor for both OS (HR 1.51, 95% CI 1.19–1.90, P = 0.001) and CSS (HR 1.50, 95% CI 1.10–2.05, P = 0.01) in 1:1 propensity score-matched analysis.ConclusionMarital status was an independent prognostic factor for G-NEN. Meanwhile, widowed patients with G-NEN had the highest risk of death compared with single, married, and divorced/separated patients.
Highlights
Marital status proves to be an independent prognostic factor in a variety of cancers
gastric neuroendocrine neoplasms (G-NEN) can be subdivided into three subtypes: type I associated with autoimmune atrophic gastritis, type II associated with Zolinger-Ellison syndrome/gastrinoma, and type III occurring sporadic without hypergastrinemia [4]
We examined the data from the Surveillance, Epidemiology, and End Results (SEER) cancer registry database to assess the effects of marital status on outcomes of patients with G-NEN
Summary
Marital status proves to be an independent prognostic factor in a variety of cancers. Its prognostic impact on gastric neuroendocrine neoplasms (G-NEN) has not been investigated. Many clinicians and nurses mainly focused on clinicopathological characteristics, without taking the impact of psychological and social factors into consideration. In reality, these sociopsychological factors do have an influence on patient outcomes [5]. Whether marriage has a “protective” effect for G-NEN patients has not yet been established. We examined the data from the Surveillance, Epidemiology, and End Results (SEER) cancer registry database to assess the effects of marital status on outcomes of patients with G-NEN
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